tailieunhanh - Báo cáo khoa học: "Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous, Intramuscular and Oral Administration to Dairy Goats"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous, Intramuscular and Oral Administration to Dairy Goats. | Acta vet. scand. 2003 44 153-159. Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous Intramuscular and Oral Administration to Dairy Goats By K. Konigsson1 K. Torneke2 K. Odensvik1 andH. Kindahl1 department of Obstetrics and Gynaecology Centre for Reproductive Biology in Uppsala and department of Pharmacology and Toxicology Faculty of Veterinary Medicine Swedish University of Agricultural Sciences Uppsala Sweden and department of Reproduction and Forensic Medicine Norwegian College of Veterinary Medicine Oslo Norway. Kõnigsson K Tõrneke K Engeland IV Odensvik K Kindahl H Pharmacokinetics and pharmacodynamic effects of flunixin after intravenous intramuscular and oral administration to dairy goats. Acta vet. scand. 2003 44 153-159. - The pharmacokinetics and the prostaglandin PG synthesis inhibiting effect of flunixin were determined in 6 Norwegian dairy goats. The dose was mg kg body weight administered by intravenous . intramuscular . and oral . routes using a cross-over design. Plasma flunixin content was analysed by use of liquid chromatography and the PG synthesis was evaluated by measuring plasma 15-ketodihydro-PGF2a by a radioim-muno-assay. Results are presented as median range . The elimination half-lives t1 were and h for . . and . administration respectively. Volume of distribution at steady state Vd was L kg and clearance CL 110 60-160 mL h kg. The plasma concentrations after oral administration showed a double-peak phenomenon with the two peaks occurring at and h respectively. Both peaks were in the same order of magnitude. Bioavailability was 79 53-112 and 58 35 -120 for . and . administration respectively. 15-Ketodihydro-PGF2a plasma concentrations decreased after flunixin administration independent of the route of administration. Introduction Flunixin is a non-steroid anti-inflammatory drug NSAID used for .