tailieunhanh - Báo cáo y học: "Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. | Respiratory Research BioMed Central Research Open Access Comprehensive evaluation of genetic variation in SI00A7 suggests an association with the occurrence of allergic rhinitis Malin Bryborn1 Christer Halldén2 Torbjorn Sall3 Mikael Adner4 and Lars Olaf Cardell 5 Address Laboratory of Clinical and Experimental Allergy Research Department of Otorhinolaryngology Malmo University Hospital Lund University Malmo Sweden 2Department of Clinical Chemistry Malmo University Hospital Malmo Sweden 3Department of Cell and Organism Biology Lund University Lund Sweden 4The National Institute of Environmental Medicine Karolinska Institutet Solna Sweden and 5Department of Otorhinolaryngology Karolinska Institutet Huddinge Sweden Email Malin Bryborn - Christer Halldén - Torbjorn Sall - Mikael Adner - Lars Olaf Cardell - Corresponding author Published 28 March 2008 Received 14 January 2008 Respiratory Research 2008 9 29 doi 1465-9921 -9-29 Accepted 28 March 2008 This article is available from http content 9 1 29 2008 Bryborn et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties. S100A7 protein levels are decreased in nasal lavage fluid from individuals with ongoing allergic rhinitis suggesting a role for S100A7 in allergic airway inflammation. The aims of this study were to describe genetic variation in SỈ00A7 and search for associations between this variation and allergic rhinitis. Methods Peripheral blood was collected from 184 atopic patients with a history of pollen-induced allergic .