tailieunhanh - Báo cáo y học: " Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus. | Respiratory Research BioMed Central Research Open Access Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus Natalie Smithy Claudia A Browningt Nathalie Duroudier Ceri Stewart Samantha Peel Caroline Swan Ian P Hall and Ian Sayers Address Division of Therapeutics Molecular Medicine University Hospital of Nottingham Nottingham UK Email Natalie Smith - mzywnas@ Claudia A Browning - c_a_browning@ Nathalie Duroudier - Ceri Stewart - Samantha Peel - msxsp@ Caroline Swan - mszcs@ Ian P Hall - Ian Sayers - Corresponding author tEqual contributors Published 28 September 2007 Received 8 June 2007 Respiratory Research 2007 8 68 doi 1465-9921 -8-68 Accepted 28 September 2007 This article is available from http content 8 1 68 2007 Smith et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Airway hyper-responsiveness AHR is a key feature of asthma and a causal relationship between airway inflammation and AHR has been identified. The aim of the current study was to clarify the effect of proinflammatory cytokines and asthma medication on primary human airway smooth muscle ASM inositol phosphate IPx signalling and define the regulatory loci involved. Methods Primary Human ASM cells were isolated from explants of trachealis muscle from individuals with no history of respiratory disease. The effect of cytokine or asthma medication on histamine or bradykinin induced IPx signalling was assessed by 3H inositol .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.