tailieunhanh - Báo cáo khoa học: "Experimental Infection of Conventional Pigs with Streptococcus suis serotype 2 by Aerosolic Exposure"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Experimental Infection of Conventional Pigs with Streptococcus suis serotype 2 by Aerosolic Exposure. | Acta vet. scand. 2001 42 303-306. Brief Communication Experimental Infection of Conventional Pigs with Streptococcus suis serotype 2 by Aerosolic Exposure By L. W. Madsen1 B. Nielsen2 B. Aal ha k H. E. Jensen1 J. P Nielsen4 and H. J. Riising2 department of Pharmacology and Pathobiology department of Veterinary Microbiology and department of Clinical Studies Royal Veterinary and Agricultural University Copenhagen and 2Intervet Scandinavia AS Skovlunde Denmark. Streptococcus suis is an important cause of meningitis arthritis and septicaemia especially in young pigs. Serotype 2 is the most prevalent type in clinical material from pigs in Europe Wisselink et al. 2000 and the infection causes severe disease outbreaks in swine herds. Different experimental models have been used to elucidate the infection but central parts of the pathogenesis still remain unclear Gottschalk Segura 2000 . In spontaneous infection S. suis is generally believed to invade via the upper respiratory tract Gottschalk Segura 2000 . Recently we described an infection model in minipigs using aerogenous challenge and subsequent steroid treatment Madsen et al. 2001a . In conventional pigs reports of models attempting aerosol exposure seem limited to a single study using anaesthetized pigs Chen-gappa et al. 1986 . In order to evaluate the pathogenesis of S. suis type 2 infection in pigs we aimed at establishing an aerosol model for the infection using unanaesthetized conventionally reared weaned pigs. The present report describes the microbiological and pathological findings in a pilot study of an aerosol model for S. suis infection in conventional pigs. Four clinically healthy 6-week-old female Landrace-Yorkshire crossbred pigs animals A-D from the same litter weaned at app. 4 weeks of age were included in this study. They were obtained from a herd with no history of disease compatible with S. suis infection and S. suis had never been isolated from the herd. For the aerosol exposure a m3 chamber