tailieunhanh - Báo cáo y học: " Controversy surrounding the increased expression of TGFβ1 in asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Controversy surrounding the increased expression of TGFβ1 in asthma. | Respiratory Research BioMed Central Review Open Access Controversy surrounding the increased expression of TGFpl in asthma Ynuk Bossé and Marek Rola-Pleszczynski Address Immunology Division Department of Pediatrics Faculty of Medicine Université de Sherbrooke Sherbrooke QC Canada Email Ynuk Bossé - ybosse@ Marek Rola-Pleszczynski - Corresponding author Published 24 September 2007 Received 15 May 2007 Accepted 24 September 2007 Respiratory Research 2007 8 66 doi 1465-9921 -8-66 This article is available from http content 8 1 66 2007 Bossé and Rola-Pleszczynski licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Asthma is a waxing and waning disease that leads to structural changes in the airways such as subepithelial fibrosis increased mass of airway smooth muscle and epithelial metaplasia. Such a remodeling of the airways futher amplifies asthma symptoms but its etiology is unknown. Transforming growth factor P1 is a pleiotropic cytokine involved in many fibrotic oncologic and immunologic diseases and is believed to play an essential role in airway remodeling that occurs in asthmatic patients. Since it is secreted in an inactive form the overall activity of this cytokine is not exclusively determined by its level of expression but also by extensive and complex post-translational mechanisms which are all importanin modulating the magnitude of the TGFP1 response. Even if TGFP1 upregulation in asthma is considered as a dogma by certain investigators in the field the overall picture of the published litterature is not that clear and the cellular origin of this cytokine in the airways of asthmatics is still a contemporaneous debate. On the .