tailieunhanh - Báo cáo y học: "Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection. | Respiratory Research BioMed Central Research Open Access Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection Paul Rennie 1 Philip Bowtell1 David Hull1 Duane Charbonneau2 Robert Lambkin-Williams3 and John Oxford3 Address 1Procter Gamble Health Sciences Institute Egham Surrey TW20 9NW UK 2Procter Gamble Health Sciences Institute Mason Ohio USA and 3Retroscreen Virology Ltd Centre for Infectious Diseases Queen Mary School of Medicine and Dentistry Medical Sciences Building 327 Mile End Road London E1 4NS UK Email Paul Rennie - Philip Bowtell - David Hull - Duane Charbonneau - Robert Lambkin-Williams - John Oxford - Corresponding author Published 17 May 2007 Received 8 February 2007 Respiratory Research 2007 8 38 doi l465-992l-8-38 Accepted 17 May 2007 This article is available from http content 8 l 38 2007 Rennie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Developing strategies for controlling the severity of pandemic influenza is a global public health priority. In the event of a pandemic there may be a place for inexpensive readily available effective adjunctive therapies to support containment strategies such as prescription antivirals vaccines quarantine and restrictions on travel. Inactivation of virus in the intranasal environment is one possible approach. The work described here investigated the sensitivity of influenza viruses to low pH and the activity of low pH nasal sprays on the course of an influenza infection in the ferret model. Methods Inactivation of .

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