tailieunhanh - Báo cáo y học: " Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study. | Respiratory Research BioMed Central Open Access Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa a clinical phase I II study Ulrich Baumann 1 Kerstin Gocke1 Britta Gewecke1 Joachim Freihorst1 2 and Bernd Ulrich von Specht3 Address Department of Paediatric Pulmonology and Neonatalogy Hanover Medical School Carl-Neuberg Str. 1 30625 Hannover Germany 2Pediatric Hospital Ostalb-Klinikum 73430 Aalen Germany and 3Centre for Clinical Research Freiburg University 79106 Freiburg Germany Email Ulrich Baumann - Kerstin Gocke - Britta Gewecke - vinatero@ Joachim Freihorst - Bernd Ulrich von Specht - Corresponding author Published 5 August 2007 Received 29 March 2007 Respiratory Research 2007 8 57 doi 1465-9921 -8-57 Accepted 5 August 2007 This article is available from http content 8 1 57 2007 Baumann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Vaccination against Pseudomonas aeruginosa is a desirable albeit challenging strategy for prevention of airway infection in patients with cystic fibrosis. We assessed the immunogenicity of a nasal vaccine based on the outer membrane proteins F and I from Pseudomonas aeruginosa in the lower airways in a phase I II clinical trial. Methods N 12 healthy volunteers received 2 nasal vaccinations with an OprF-OprI gel as a primary and a systemic n 6 or a nasal booster vaccination n 6 . Antibodies were assessed in induced .