tailieunhanh - Báo cáo y học: "Maternal allergic contact dermatitis causes increased asthma risk in offspring"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Maternal allergic contact dermatitis causes increased asthma risk in offspring. | Respiratory Research BioMed Central Open Access Maternal allergic contact dermatitis causes increased asthma risk in offspring Robert H Lim1 Mohamed S Arredouani2 Alexey Fedulov1 Lester Kobzik 1 3 and Cedric Hubeau4 Address Department of Environmental Health Harvard School of Public Health Boston MA USA 2Department of Surgery Beth-Israel Deaconess Medical Center Harvard Medical School Boston MA USA 3Department of Pathology Brigham Women s Hospital Boston MA USA and 4Department of Biology Momenta Pharmaceuticals Inc. Cambridge MA USA Email Robert H Lim - rlim@ Mohamed S Arredouani - marredou@ Alexey Fedulov - afedulov@ Lester Kobzik - lkobzik@ Cedric Hubeau - chubeau@ Corresponding author Published 27 July 2007 Received 10 April 2007 Respiratory Research 2007 8 56 doi 1465-9921 -8-56 Accepted 27 July 2007 This article is available from http content 8 1 56 2007 Lim et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Offspring of asthmatic mothers have increased risk of developing asthma based on human epidemiologic data and experimental animal models. The objective of this study was to determine whether maternal allergy at non-pulmonary sites can increase asthma risk in offspring. Methods BALB c female mice received 2 topical applications of vehicle dinitrochlorobenzene or toluene diisocyanate before mating with untreated males. Dinitrochlorobenzene is a skin-sensitizer only and known to induce a Th1 response while toluene diisocyanate is both a skin and respiratory sensitizer that causes a Th2 response. Both .