tailieunhanh - Báo cáo y học: "Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. | BioMed Central Respiratory Research Research Open Access Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration Reinhold Schmidt Philipp Markart Clemens Ruppert Malgorzata Wygrecka Tim Kuchenbuch Dieter Walmrath Werner Seeger and Andreas Guenther Address University of Giessen Lung Center UGLC Medical Clinic II Giessen Germany Email Reinhold Schmidt - Philipp Markart - Clemens Ruppert - Malgorzata Wygrecka - Tim Kuchenbuch - Dieter Walmrath - Werner Seeger - Andreas Guenther - Corresponding author Published 27 July 2007 Received 22 February 2007 Respiratory Research 2007 8 55 doi 1465-9921 -8-55 Accepted 27 July 2007 This article is available from http content 8 1 55 2007 Schmidt et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alterations to pulmonary surfactant composition have been encountered in the Acute Respiratory Distress Syndrome ARDS . However only few data are available regarding the time-course and duration of surfactant changes in ARDS patients although this information may largely influence the optimum design of clinical trials addressing surfactant replacement therapy. We therefore examined the time-course of surfactant changes in 15 patients with direct ARDS pneumonia aspiration over the first 8 days after onset of mechanical .