tailieunhanh - Báo cáo khoa học: "Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies. | Acta vet. scand. 2004 45 133-137. Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies By J. S. Agerholm1 O. Andersen3 M. B. Almskou3 C. Bendixen4 J. Arnbjerg2 G. P Aamand3 U. S. Nielsen3 F Panitz4 and . Petersen4 laboratory of Pathology Department of Veterinary Pathobiology and 2Department of Clinical Studies Radiology The Royal Veterinary and Agricultural University Frederiksberg 3Danish Cattle Skejby and institute of Agricultural Sciences Department of Animal Breeding and Genetics Tjele Denmark. Agerholm JS Andersen O Almskou MB Bendixen C Arnbjerg J Aamand GP Nielsen US Panitz F Petersen AH Evaluation of the inheritance of the complex vertebral malformation syndrome by breeding studies. Acta vet. scand. 2004 45 133-137. - To investigate the congenital complex vertebral malformation syndrome CVM in Holstein calves two breeding studies were performed including 262 and 363 cows respectively. Cows were selected from the Danish Cattle Database based on pedigree and insemination records. Selected cows were progeny of sires with an established heterozygous CVM genotype and pregnant after insemination with semen from another sire with heterozygous CVM genotype. Following calving the breeders should state if the calf was normal and was requested to submit dead calves for necropsy. In both studies significantly fewer CVM affected calves than expected were obtained a finding probably reflecting extensive intrauterine mortality in CVM affected foetuses. The findings illustrate increased intrauterine mortality as a major potential bias in observational studies of inherited disorders. Complex vertebral malformation CVM abortion congenital Holstein cattle. Introduction Complex vertebral malformation CVM is a lethal syndrome of Holstein cattle which in premature and mature calves is characterised by congenital growth retardation malformed vertebrae and tetramelic arthrogryposis Ager-holm et al. 2001 . Genomic studies have shown .