tailieunhanh - Báo cáo y học: " Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. | Respiratory Research BioMed Central Open Access Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics Sushma Komakula1 Sumita Khatri2 Joel Mermis1 Samira Savill1 Shireen Haque1 Mauricio Rojas1 LouAnn Brown3 Gerald W Teague3 and Fernando Holguin 1 4 Address Department of Medicine Emory University Atlanta USA 2Department of Medicine Case Western Ohio USA Department of Pediatrics Emory University Atlanta USA and 4Davis-Fischer Building 550 Peachtree Street NE 2nd Floor Room 2331 Atlanta GA 30308 USA Email Sushma Komakula - skomaku@ Sumita Khatri - skhatri@ Joel Mermis - jmermis@ Samira Savill - Shireen Haque - shaque2@ Mauricio Rojas - mrojas@ LouAnn Brown - Gerald WTeague - Fernando Holguin - fch5@ Corresponding author Published 16 April 2007 Received 28 December 2006 Respiratory Research 2007 8 32 doi 1465-9921 -8-32 Accepted 16 April 2007 This article is available from http content 8 1 32 2007 Komakula et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Recently it has been shown that increasing body mass index BMI in asthma is associated with reduced exhaled NO. Our objective in this study was to determine if the BMI-related changes in exhaled NO differ across asthmatics and controls and to determine if these changes are related to increased airway oxidative stress and systemic levels of leptin and adiponectin. Methods Observational study of the association of BMI .