tailieunhanh - Báo cáo y học: " Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells Seijitsu Ando1,2, Hitomi Otani1, Yasuhiro Yagi2, Kenzo Kawai3, Hiromasa Araki3, Shirou Fukuhara2 and Chiyoko "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells Seijitsu Ando1,2, Hitomi Otani1, Yasuhiro Yagi2, Kenzo Kawai3, Hiromasa Araki3, Shirou Fukuhara2 and Chiyoko. | Respiratory Research BioMed Central Open Access Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells Seijitsu Ando1 2 Hitomi Otani1 Yasuhiro Yagi2 Kenzo Kawai3 Hiromasa Araki3 Shirou Fukuhara2 and Chiyoko Inagaki 1 Address Department of Pharmacology Kansai Medical University 10-15 Fumizono-Cho Moriguchi Osaka 570-8506 Japan 2The First Department of Internal Medicine Kansai Medical University 10-15 Fumizono-Cho Moriguchi Osaka 570-8506 Japan and 3Fuso Pharmaceutical Industries Ltd. Joto-ku Osaka 536-8523 Japan Email Seijitsu Ando - andos@ Hitomi Otani - otani@ Yasuhiro Yagi - yagiy@ Kenzo Kawai - k-kawai@ Hiromasa Araki - h-araki@ Shirou Fukuhara - fukuhara@ Chiyoko Inagaki - inagaki@ Corresponding author Published 16 April 2007 Received 19 January 2007 Respiratory Research 2007 8 31 doi 1465-9921 -8-31 Accepted 16 April 2007 This article is available from http content 8 1 3 1 2007 Ando et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Proteinase-activated receptors PARs PAR1-4 that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases including fibrosis. Among these PARs especially PAR4 a newly identified subtype is highly expressed in the lung. Here we examined whether PAR4 stimulation plays a role in the formation of fibrotic response in the lung through alveolar epithelial-mesenchymal transition EMT which contributes to