tailieunhanh - Báo cáo y học: " Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18 J Foster Harris1, Jay Aden1, C Rick Lyons2 and "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18 J Foster Harris1, Jay Aden1, C Rick Lyons2 and . | Respiratory Research BioMed Central Research Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18 J Foster Harris1 Jay Aden1 C Rick Lyons2 and Yohannes Tesfaigzi 1 Open Access Address 1Lovelace Respiratory Research Institute Albuquerque NM USA and 2University of New Mexico Albuquerque NM USA Email J Foster Harris - jharris@ Jay Aden - jaden@ C Rick Lyons - crlyons@ YohannesTesfaigzi - ytesfaig@ Corresponding author Published 12 March 2007 Received 7 September 2006 Respiratory Research 2007 8 24 doi 1465-9921 -8-24 Accepted 12 March 2007 This article is available from http content 8 1 24 2007 Harris et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The resolution of inflammatory responses in the lung has not been described in detail and the role of specific cytokines influencing the resolution process is largely unknown. Methods The present study was designed to describe the resolution of inflammation from 3 h through 90 d following an acute injury by a single intratracheal instillation of F344 N rats with LPS. We documented the inflammatory cell types and cytokines found in the bronchoalveolar lavage fluid BALF and epithelial changes in the axial airway and investigated whether IL-18 may play a role in the resolution process by reducing its levels with anti-IL-18 antibodies. Results Three major stages of inflammation and resolution were observed in the BALF during the resolution. The first stage was characterized by PMNs that increased over 3 h to 1 d and decreased to background levels by d 6-8. The .