tailieunhanh - Báo cáo y học: " Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts. | Respiratory Research BioMed Central Research Open Access Cigarette smoke exposure inhibits extracellular MMP-2 gelatinase A activity in human lung fibroblasts Giampiero La Rocca f Rita Anzalonef Francesca Magno Felicia Farina Francesco Cappello and Giovanni Zummo Address Sezione di Anatomia Umana Dipartimento di Medicina Sperimentale Università degli Studi di Palermo Via del Vespro 129 90127 Palermo Italy Email Giampiero La Rocca - giampylr@ Rita Anzalone - ranzalone@ Francesca Magno - francymagno@ Felicia Farina - liciafarina@ Francesco Cappello - francapp@ Giovanni Zummo - gzummo@ Corresponding author tEqual contributors Published 12 March 2007 Received 21 June 2006 Respiratory Research 2007 8 23 doi 1465-9921 -8-23 Accepted 12 March 2007 This article is available from http content 8 1 23 2007 La Rocca et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exposure to cigarette smoke is considered a major risk factor for the development of lung diseases since its causative role has been assessed in the induction and maintenance of an inflamed state in the airways. Lung fibroblasts can contribute to these processes due to their ability to produce proinflammatory chemotactic molecules and extracellular matrix remodelling proteinases. Among proteolytic enzymes gelatinases A and B have been studied for their role in tissue breakdown and mobilisation of matrix-derived signalling molecules. Multiple reports linked gelatinase deregulation and overexpression to the development of inflammatory chronic lung diseases such as COPD. Methods In this study we aimed to determine variations in the gelatinolytic pattern of human .