tailieunhanh - Báo cáo y học: " Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD. | Respiratory Research BioMed Central Research Open Access Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of Copd Hiroshi Kanazawa Kazuhisa Asai and Saeko Nomura Address Department of Respiratory Medicine Graduate School of Medicine Osaka City University 1-4-3 Asahi-machi Abenoku Osaka 5458585 Japan Email Hiroshi Kanazawa - kanazawa-h@ Kazuhisa Asai - Saeko Nomura - Saeko6@ Corresponding author Published 8 March 2007 Received 14 September 2006 Respiratory Research 2007 8 22 doi 1465-9921 -8-22 Accepted 8 March 2007 This article is available from http content 8 1 22 2007 Kanazawa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor VEGF . This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD. Methods VEGF levels in induced sputum were examined in 23 control subjects 12 non-smokers and 11 ex-smokers and 29 patients with bronchitis-type of COPD. All bronchitis-type patients performed exercise testing with right heart catheterization. Results The mean pulmonary arterial pressure mPAP and pulmonary vascular resistance PVR after exercise were markedly increased in all bronchitis-type patients. However both parameters after exercise with breathing of oxygen was significantly lower than in those with breathing of room air. To attenuate the effect of hypoxia-induced pulmonary vasoconstriction during exercise we used the .