tailieunhanh - Báo cáo khoa học: " Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review. | Acta vet. scand. 2002 43 63-74. Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes A Review By A. R. Poso Department of Basic Veterinary Sciences University of Helsinki Finland. Poso AR Monocarboxylate transporters and lactate metabolism in equine athletes A review. Acta vet. scand. 2002 43 63-74. - Lactate is known as the end product of anaerobic glycolysis a pathway that is of key importance during high intensity exercise. Instead of being a waste product lactate is now regarded as a valuable substrate that significantly contributes to the energy production of heart noncontracting muscles and even brain. The recent cloning of monocarboxylate transporters a conserved protein family that transports lactate through biological membranes has given a new insight into the role of lactate in whole body metabolism. This paper reviews current literature on lactate and monocarboxylate transporters with special reference to horses. Horse MCT skeletal muscle Red blood cell Exercise. Introduction Horses are superb athletes in comparison to other athletic species. Exceptionally high maximal oxygen uptake a splenic reserve of red blood cells released into the circulation during exercise and a high amount of energy stored as glycogen in the muscles contribute to the high performance capacity of a horse Jones 1989 Derman Noakes 1994 . Furthermore equine muscles and blood are equipped with properties that increase their tolerance to lactic acid the formation of which is necessary for maximal performance. The buffer capacity of muscles of trained horses is higher than in other athletic species and red blood cells appear to function as a lactate sink both of which phenomena may increase the anaerobic capacity McCutcheon et al. 1987 Poso et al. 1995 . Because the lactic acid-induced acidification is the single most important factor causing fatigue the regulation of its concentration in exercising muscle plays a central role in muscle function. Recent .

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