tailieunhanh - Báo cáo y học: "Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial. | Rantalaiho et al. Arthritis Research Therapy 2010 12 R122 http content 12 3 R122 RESEARCH ARTICLE Open Access Earlyicombination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial Vappu Rantalaiho 1 Markku Korpela1 Leena Laasonen2 Hannu Kautiainen3 5 Salme Jarvenpaa4 Pekka Hannonen5 Marjatta Leirisalo-Repo6 Harri Blafield7 Kari Puolakka8 Anna Karjalainen9 Timo Mõttõnen10 for the FIN-RACo Trial Group Abstract Introduction Early treatment of rheumatoid arthritis RA has been shown to retard the development of joint damage for a period of up to 5 years. The aim of this study was to evaluate the radiologic progression beyond that time in patients with early RA initially treated with a combination of three disease-modifying antirheumatic drugs DMARDs or a single DMARD. Methods A cohort of 199 patients with early active RA were initially randomized to receive treatment with a combination of methotrexate sulfasalazine and hydroxychloroquine with prednisolone FIN-RACo or treatment with a single DMARD initially sulfasalazine with or without prednisolone SINGLE . After 2 years the drug-treatment strategy became unrestricted but still targeted remission. The radiographs of hands and feet were analyzed by using the Larsen score at baseline 2 5 and 11 years and the radiographs of large joints at 11 years. Results Sixty-five patients in the FIN-RACo and 65 in the SINGLE group had radiographs of hands and feet available at baseline and at 11 years. The mean change from baseline to 11 years in Larsen score was 17 95 CI 12 to 26 in the FIN-RACo group and 27 95 CI 22 to 33 in the SINGLE group P . In total 87 95 CI 74 to 94 and 72 95 CI 58 to 84 of the patients in the FIN-RACo and the SINGLE treatment arms respectively had no erosive changes in large joints at 11 years. .

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