tailieunhanh - Báo cáo y học: "Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. | Hollis-Moffatt et al. Arthritis Research Therapy 2010 12 R116 http content 12 3 R116 RESEARCH ARTICLE Open Access Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance Jade E Hollis-Moffatt41 Michael Chen-Xu41 Ruth Topless 1 Nicola Dalbeth2 Peter J Gow3 Andrew A Harrison4 John Highton5 Peter BB Jones2 Michael Nissen6 Malcolm D Smith6 Andre van Rij7 GregoryT Jones7 Lisa KStamp8 and Tony R Merriman 1 Abstract Introduction The single nucleotide polymorphism SNP rs6822844 within the KIAA1109-TENR-IL2-IL21 gene cluster has been associated with rheumatoid arthritis RA . Other variants within this cluster including rs17388568 that is not in linkage disequilibrium LD with rs6822844 and rs907715 that is in moderate LD with rs6822844 and rs17388568 have been associated with a number of autoimmune phenotypes including type 1 diabetes T1D . Here we aimed to one confirm at a genome-wide level of significance association of rs6822844 with RA and two evaluate whether or not there were effects independent of rs6822844 on RA at the KIAA1109-TENR-IL2-IL21 locus. Methods A total of 842 Australasian RA patients and 1 115 controls of European Caucasian ancestry were genotyped for rs6822844 rs17388568 and rs907715. Meta-analysis of these data with published and publicly-available data was conducted using STATA. Results No statistically significant evidence for association was observed in the Australasian sample set for rs6822844 odds ratio OR to P or rs17388568 OR to P or rs907715 OR to P . When combined in a meta-analysis using data from a total of 9 772 cases and 10 909 controls there was a genome-wide level of significance supporting association of rs6822844 with RA OR to P X 10-8 P X 10-8 including