tailieunhanh - Báo cáo y học: " Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin– angiotensin system in inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin– angiotensin system in inflammation. | Chappell Arthritis Research Therapy 2010 12 128 http content 12 3 128 EDITORIAL L_ Angiotensin-converting enzyme 2 autoantibodies further evidence for a role of the reninangiotensin system in inflammation Mark C Chappell See related research by Takahashi etal. http content 12 3 R85 Abstract Traditionally viewed as important in the regulation of blood pressure the renin-angiotensin system - and specifically the angiotensin-converting enzyme ACE -angiotensin Ang II-AT1 receptor axis - may play a prominent role to promote inflammation and fibrosis. ACE2 a new component of the renin-angiotensin system has emerged as a key enzyme that selectively degrades Ang II and generates Ang- 1-7 a bioactive peptide with anti-inflammatory and anti-fibrotic actions. Takahashi and colleagues demonstrate circulating titers of inhibitory autoantibodies against ACE2 in patients with systemic sclerosis. The current study reveals a potentially novel mechanism to attenuate the catalytic activity of ACE2 thereby promoting the actions of Ang II. The discovery of the angiotensin-converting enzyme ACE homolog ACE2 EC has provoked intensive efforts to elucidate the role of this enzyme in various pathologies including hypertension diabetes heart failure viral infection pulmonary injury and liver fibrosis. The biological relevance of ACE2 reflects its critical location in the enzymatic cascade of the reninangiotensin system to directly govern the local expression of angiotensin Ang II and Ang- 1-7 two bioactive hormones with significant and opposing actions. In the present issue of Arthritis Research Therapy Takahashi and colleagues assessed circulating levels of ACE2 in patients with connective tissue pathologies including pulmonary hypertension and persistent digital Correspondence mchappel@ Hypertension and Vascular Disease Center Wake Forest School of Medicine Medical Center Boulevard Winston-Salem NC 27015 USA 2 BioMed