tailieunhanh - CHAPTER 2: CARBONHYDRATE METABOLISM- GLYCOLYTIC ENZYMES

- Polysaccharides are macromolecules, polymers with a few hundred to a few thousand monosaccharides joined by glycosidic linkages. - Some polysaccharides serve as storage material, hydrolyzed as needed to provide sugar for cells. - Other polysaccharides serve as building material for structures that protect the cell or the whole organism. - The architecture and function of a polysaccharide are determined by its sugar monomers and by the positions of its glycosidic linkages. | CHAPTER 2: CARBONHYDRATE METABOLISM- GLYCOLYTIC ENZYMES INTERNATIONAL UNIVERSITY SCHOOL OF BIOTECHNOLOGY BIOCHEMISTRY Learning objectives 1. Review the carbonhydrates 2. Learn the names of the 10 enzymes of glycolysis. 3. Learn the structures of the intermediates in the glycolytic pathway. 4. Explore the structures of the glycolytic enzymes. 5. Understand the chemical mechanisms of the enzymes of glycolysis. Brief Content carbonhydrate glycolytic enzymes Hexokinase Phosphoglucose Isomerase Phosphofructokinase Aldolase Triose phosphate Isomerase Glyceraldehide-3- phosphate dehydrogenase Phosphoglycerate kinase Phosphoglycerate mutase Enolase Pyruvate kinase Detailed Content carbonhydrate glycolytic enzymes Hexokinase Structure Catalytic mechanism Active site details Phosphoglucose Isomerase Structure Catalytic mechanism Active site details Detailed Content Phosphofructokinase Structure Catalytic . | CHAPTER 2: CARBONHYDRATE METABOLISM- GLYCOLYTIC ENZYMES INTERNATIONAL UNIVERSITY SCHOOL OF BIOTECHNOLOGY BIOCHEMISTRY Learning objectives 1. Review the carbonhydrates 2. Learn the names of the 10 enzymes of glycolysis. 3. Learn the structures of the intermediates in the glycolytic pathway. 4. Explore the structures of the glycolytic enzymes. 5. Understand the chemical mechanisms of the enzymes of glycolysis. Brief Content carbonhydrate glycolytic enzymes Hexokinase Phosphoglucose Isomerase Phosphofructokinase Aldolase Triose phosphate Isomerase Glyceraldehide-3- phosphate dehydrogenase Phosphoglycerate kinase Phosphoglycerate mutase Enolase Pyruvate kinase Detailed Content carbonhydrate glycolytic enzymes Hexokinase Structure Catalytic mechanism Active site details Phosphoglucose Isomerase Structure Catalytic mechanism Active site details Detailed Content Phosphofructokinase Structure Catalytic mechanism Active site details Aldolase Structure Catalytic mechanism Active site details Detailed Content Triose phosphosphate Isomerase Structure Catalytic mechanism Active site details Glycealdehide-3- phosphate dehydrogenase Structure Catalytic mechanism Active site details Detailed Content Phosphoglycerate kinase Structure Catalytic mechanism Active site details Phosphoglycerate mutase Structure Catalytic mechanism Active site details Detailed Content Enolase Structure Catalytic mechanism Active site details Pyruvate kinase Structure Catalytic mechanism Active site details 1 CARBOHYDRATES: * Sugars, the smallest carbohydrates, serve as fuel and carbon sources * Polysaccharides, the polymers of sugars, have storage and structural roles Carbohydrates include both sugars and their polymers. The simplest carbohydrates are the monosaccharides, or single sugars, also known as simple sugars. Disaccharides are double sugars, consisting of two .