tailieunhanh - Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study. | Pappas et al. Arthritis Research Therapy 2010 12 R104 http content 12 3 R104 RESEARCH ARTICLE Open Access Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis an observational cohort study Dimitrios A Pappas Jon T Giles Geoffrey Connors Noah Lechtzin Joan M Bathon and Sonye K Danoff Abstract Introduction Lung involvement is a common extra-articular manifestation of rheumatoid arthritis RA that confers significant morbidity and mortality. The objective of the present study is to assess which respiratory symptoms and patient and disease characteristics are most highly associated with pulmonary function test PFT abnormalities in an RA patient cohort without clinical cardiovascular disease. Methods A total of 159 individuals with RA and without clinically evident cardiovascular disease were evaluated. Respiratory symptoms were assessed with the Lung Tissue Research Consortium questionnaire and all patients underwent evaluation with PFTs. Demographic lifestyle RA disease and treatment characteristics were collected. Subclinical coronary artery disease was assessed by cardiac computed tomography. Multivariable regression analysis was used to identify pulmonary symptoms and nonpulmonary parameters associated with PFT abnormalities. Areas under the receiver operating characteristic curves AUC were calculated to evaluate the discrimination of these variables for identifying patients with PFT abnormalities. Results Respiratory symptoms were reported by 42 of the patient population. Although only 6 carried a prior diagnosis of lung disease PFT abnormalities were identified in 28 of the subjects. Symptoms combined with other patient and RA characteristics body mass index current smoking anti-cyclic citrullinated peptide antibodies and current prednisone use performed satisfactorily in predicting the PFT abnormalities of obstruction AUC 95 confidence interval to