tailieunhanh - Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction

Obesity is associated with a high prevalence of erectile dysfunction; how-ever, the pathophysiological link between obesity and erectile dysfunction remains poorly understood. In this minireview, we have attempted to eval-uate the existing literature pertaining to obesity and erectile dysfunction to determine whether a common pathophysiological link exists. | ỊFEBS Journal MINIREVIEW Mechanisms of obesity and related pathologies Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction Abdulmaged M. Traish1 Robert J. Feeley1 and Andre Guay2 1 Department of Biochemistry and Urology Boston University Schoolof Medicine MA USA 2 Department of Endocrinology Center for SexualFunction Lahey Clinic Peabody MA USA Keywords diabetes dyslipidemia endothelial dysfunction erectile dysfunction hypogonadism inflammatory responses metabolic syndrome testosterone deficiency vascular disease visceralobesity Correspondence A. M. Traish Laboratories for Sexual Medicine Institute for SexualMedicine Boston University Schoolof Medicine Center for Advanced Biomedical Research 700 Albany Street W607 Boston MA 02118 USA Fax 1 617 638 5412 Tel 1 617 638 4578 E-mail atraish@ Received 27 February 2009 revised 31 July 2009 accepted 3 August 2009 doi Obesity is associated with a high prevalence of erectile dysfunction however the pathophysiological link between obesity and erectile dysfunction remains poorly understood. In this minireview we have attempted to evaluate the existing literature pertaining to obesity and erectile dysfunction to determine whether a common pathophysiological link exists. Visceral obesity is associated with increased inflammatory responses which contribute to endothelial dysfunction. Furthermore obesity is also associated with reduced plasma testosterone levels which contributes to hypogonadism and increases the risk of vascular pathology. Endothelial dysfunction and androgen deficiency have previously been linked to the pathophysiological mechanisms of erectile dysfunction. The underlying pathophysiological mechanisms of endothelial dysfunction and testosterone deficiency include penile vascular insufficiency as a result of the loss of nitric oxide synthase expression and activity and the loss of tissue compliance resulting in reduced .