tailieunhanh - Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development

Obesity and its associated disorders, including diabetes and cardiovascular disease, have now reached epidemic proportions in the Western world, resulting in dramatic increases in healthcare costs. Understanding the pro-cesses and metabolic perturbations that contribute to the expansion of adi-pose depots accompanying obesity is central to the development of appropriate therapeutic strategies. | ỊFEBS Journal MINIREVIEW Mechanisms of obesity and related pathologies Transcriptional control of adipose tissue development Cecile Vernochet Sidney B. Peres and Stephen R. Farmer Department of Biochemistry Boston University Schoolof Medicine Boston MA USA Keywords brown adipose tissue obesity progenitors PPAR gamma white adipose tissue Correspondence S. R. Farmer Department of Biochemistry Boston University Schoolof Medicine 715 Albany Street Boston MA 02118 USA Fax 1 617 638 5339 Tel 1 617 638 4186 E-mail farmer@ Received 25 March 2009 revised 5 August 2009 accepted 13 August 2009 doi Obesity and its associated disorders including diabetes and cardiovascular disease have now reached epidemic proportions in the Western world resulting in dramatic increases in healthcare costs. Understanding the processes and metabolic perturbations that contribute to the expansion of adipose depots accompanying obesity is central to the development of appropriate therapeutic strategies. This minireview focuses on a discussion of the recent identification of molecular mechanisms controlling the development and function of adipose tissues as well as how these mechanisms contribute to the regulation of energy balance in mammals. Introduction Obesity is a worldwide epidemic and a major contributor to the development of a group of potentially life-threatening conditions referred to as the metabolic syndrome. This syndrome groups together several pathologies that can coexist including insulin resistance type II diabetes dyslipidemia cardiovascular disease inflammation and some cancers and all have a strong association with intra-abdominal adipose tissue mass 1 . Consequently obesity has a significant cost on the well being of society because the incidence of these diseases is expected to double by the year 2030 and the associated healthcare expenditure will be 100 billion in the USA alone 2 3 . The increased incidence of obesity .