tailieunhanh - Báo cáo khoa học: Is there more to aging than mitochondrial DNA and reactive oxygen species?

With the aging of the population, we are seeing a global increase in the prevalence of age-related disorders, especially in developed countries. Chronic diseases disproportionately affect the older segment of the popula-tion, contributing to disability, a diminished quality of life and an increase in healthcare costs. | REVIEW ARTICLE Is there more to aging than mitochondrial DNA and reactive oxygen species Mikhail F. Alexeyev1 2 1 Department of CellBiology and Neuroscience University of South Alabama Mobile AL USA 2 Institute of Molecular Biology and Genetics Kyiv Ukraine Keywords antioxidants lifespan extension mitochondria mitochondrial DNA degradation mitochondrial DNA mutations mitochondrial DNA repair mitochondrial theory of aging oxidative damage Correspondence M. Alexeyev University of South Alabama Department Cell Biology and Neuroscience 307 University Blvd. MSB1201 Mobile AL 36688 USA Fax 1 251 460 6771 Tel 1 251 460 6789 E-mail malexeye@ Received 12 July 2009 revised 3 August 2009 accepted 11 August 2009 With the aging of the population we are seeing a global increase in the prevalence of age-related disorders especially in developed countries. Chronic diseases disproportionately affect the older segment of the population contributing to disability a diminished quality of life and an increase in healthcare costs. Increased life expectancy reflects the success of contemporary medicine which must now respond to the challenges created by this achievement including the growing burden of chronic illnesses injuries and disabilities. A well-developed theoretical framework is required to understand the molecular basis of aging. Such a framework is a prerequisite for the development of clinical interventions that will constitute an efficient response to the challenge of age-related health issues. This review critically analyzes the experimental evidence that supports and refutes the Free Radi-cal Mitochondrial Theory of Aging which has dominated the field of aging research for almost half a century. doi Introduction Aging is a multifactorial phenomenon characterized by a time-dependent decline in physiological function 1 . This decline is believed to be associated with an accumulation of defects in metabolic pathways. More .

• Báo cáo khoa học
• scientific reports
• thesis report
• medical report
• With the aging of the population
• we are seeing a global increase in the prevalence of age related disorders
• especially in developed countries
• Chronic diseases disproportionately affect the older segment of the popula tion
• contributing to disability
• a diminished quality of life and an increase in healthcare costs