tailieunhanh - Báo cáo khoa học: Evolutionary changes to transthyretin: structure–function relationships

Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and⁄or cerebrospinal fluid of vertebrates. It transports retinol via binding to retinol-binding protein, and exists mainly as a homotetrameric protein of 55 kDa in plasma. The first 3D structure of transthyretin was an X-ray crystal structure from human transthyretin. | MINIREVIEW Evolutionary changes to transthyretin structure-function relationships P. Prapunpoj and L. Leelawatwattana Department of Biochemistry Faculty of Science Prince of Songkla University Hat Yai Thailand Keywords binding affinity evolution function plasma protein protease retinol-binding protein splicing structure thyroid hormone transthyretin Correspondence Porntip Prapunpoj Department of Biochemistry Faculty of Science Prince of Songkla University Hat Yai Songkhla 90112 Thailand Fax 66 74 446656 Tel 66 74 288275 E-mail Received 2 February 2009 revised 5 July 2009 accepted 27 July 2009 doi Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and or cerebrospinal fluid of vertebrates. It transports retinol via binding to retinol-binding protein and exists mainly as a homotetrameric protein of 55 kDa in plasma. The first 3D structure of transthyretin was an X-ray crystal structure from human transthyretin. Elucidation of the structure-function relationship of transthyretin has been of significant interest since its highly conserved structure was shown to be associated with several aspects of metabolism and with human diseases such as amyloidosis. Transthyretin null mice do not have an overt phenotype probably because transthyretin is part of a network with other thyroid hormone distributor proteins. Systematic study of the evolutionary changes of transthyretin structure is an effective way to elucidate its function. This review summarizes current knowledge about the evolution of structural and functional characteristics of vertebrate transthyretins. The molecular mechanism of evolutionary change and the resultant effects on the function of transthyretin are discussed. Introduction Transthyretin is a major protein in extracellular fluids and it binds thyroid hormones THs in both L-3 5 3 -triiodothyronine T3 and L-thyroxine T4 forms. It was first identified in human cerebrospinal

• Báo cáo khoa học
• scientific reports
• thesis report
• medical report
• Crystal structure
• medical analysis
• biochemical studies
• Zizyphus mauritiana Lamk
• Biochemical constitutes
• Ber selection 1
• Studies on the pattern
• Pattern of changes biochemical constitutes
• Studies on Tikka disease
• Tikka disease
• Sowing dates
• Biochemical parameters of groundnut
• Biochemical parameters
• Studies on biochemical changes
• Biochemical changes
• Cell wall degrading enzymes
• Papaya fruit inoculated
• Colletotrichum demetium
• Vindhyan zone
• Haemato biochemical profile
• Haemato biochemical profile of goats
• Goats in Vindhyan region
• Biochemical variables
• Diaphragmatic hernia
• Various NSAIDS protocols affected
• Buffaloes treated
• Biochemical composition
• Reducing and Non reducing sugar
• Non reducing sugar
• Biochemical composition of various tomato
• Various tomato (Solanum lycopersicum L )
• Report medicine
• traditional medicine
• environmental medicine
• Hepatobiliary disorders
• Serum biochemistry
• Hemato biochemical studies
• Hepatobiliary disorders in dogs
• Elevated total leucocyte
• Agricultural science
• Physiological and biochemical studies
• Wheat plants by application
• Amino acids and yeast extract
• Physio chemical
• Water relations
• Lucknow 49
• Ascarbic acid
• Different cultivars
• Guava under eastern
• Biochemical studies on adverse health
• Adverse health effects of arsenic
• Chromium in buffaloes
• Level of arsenic and chromium
• Heavy metals in buffaloes
• PyometraCEH complex
• Haemato biochemical evaluation
• Bitches affected
• Cystic endometrial hyperplasia pyometra complex
• Haemato biochemical studies
• Sloth bears
• HematoBiochemical changes
• Biochemical values
• Hemato biochemical changes
• Xylazine Zolazepam
• Sahiwal cows
• Blood metabolites
• Complete lactation in Sahiwal cows
• breast cancer
• medicine
• Hematopoietic
• medical knowledge