tailieunhanh - Báo cáo y học: "Effect of duloxetine in patients with fibromyalgia: tiredness subgroups"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Effect of duloxetine in patients with fibromyalgia: tiredness subgroups. | Bradley et al. Arthritis Research Therapy 2010 12 R141 http content 12 4 R141 RESEARCH ARTICLE Open Access Effect of duloxetine in patients with fibromyalgia tiredness subgroups I n I I A Dr m I r1 D - 4-4-2 Im A HZA I D I ir-r -JI3h mi IV I Ạ z . L I v- - I r p. 4 A r A r c k k . I 15 6 Cl III I m A z t 7 Laurence A Bradley Robert Dennett Irwin J Russell Maueiaine M vvohireich Amy S Chappell rujun Wang Deborah N D Souza8 Harvey Moldofsky9 Abstract Introduction This study tested the hypothesis that baseline ratings of fatigue tiredness would be negatively associated with the efficacy of duloxetine on measures of pain and functional ability in patients with fibromyalgia. Methods A post hoc analysis of pooled data from 4 double-blind placebo-controlled studies of duloxetine in fibromyalgia was performed. The fibromyalgia impact questionnaire FIQ tiredness item score 0 to 10 scale was used to define tiredness subgroups. Patients were stratified into 3 subgroups mild 0 to 3 moderate 4 to 6 and severe 7 to 10 tiredness. Analysis of covariance models and logistic regressions were used to test treatment-by-tiredness subgroup interactions. Results Data from the first 3 months are included in this post hoc analysis duloxetine N 797 placebo N 535 . At baseline the distribution of tiredness severity in the duloxetine and placebo groups respectively was and mild and moderate and and severe. Rates of clinically significant 30 and 50 improvement in brief pain inventory BPI average pain were similar across the tiredness subgroups. Tiredness severity at baseline was not negatively associated with the effects of duloxetine on patients reports of functional ability using the FIQ total score FIQ measures of physical impairment interference with work pain stiffness and depression and the medical outcomes study short form-36 SF-36 . Conclusions Studies of duloxetine in fibromyalgia have demonstrated clinically significant .