tailieunhanh - Báo cáo y học: "Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? | Brennan et al. Arthritis Research Therapy 2010 12 R139 http content 12 4 R139 RESEARCH ARTICLE Open Access Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women 1 1 2 1 2 Sharon L Brennan Flavia M Cicuttini Julie A Pasco Margaret J Henry Yuanyuan Wang Mark A Kotowicz Geoff C Nicholson2 Anita E Wluka 1 Abstract Introduction Although obesity is a modifiable risk factor for knee osteoarthritis OA the effect of weight gain on knee structure in young and healthy adults has not been examined. The aim of this study was to examine the relationship between body mass index BMI and change in BMI over the preceding 10-year period and knee structure cartilage defects cartilage volume and bone marrow lesions BMLs in a population-based sample of young to middle-aged females. Methods One hundred and forty-two healthy asymptomatic females range 30 to 49 years in the Barwon region of Australia underwent magnetic resonance imaging MRI during 2006 to 2008. BMI measured 10 years prior 1994 to 1997 current BMI and change in BMI accounting for baseline BMI over this period was assessed for an association with cartilage defects and volume and BMLs. Results After adjusting for age and tibial plateau area the risk of BMLs was associated with every increase in one-unit of baseline BMI Or 95 CI to P current BMI OR 95 CI to P and per one unit increase in BMI OR 95 CI to P . There was a trend for a one-unit increase in current BMI to be associated with increased risk of cartilage defects OR 95 CI to P and a suggestion that a one-unit increase in BMI over 10 years may be associated with reduced cartilage volume ml 95 CI to P . Results remained similar after excluding those with osteophytes. Conclusions This study provides longitudinal evidence for the importance of avoiding weight gain in women during