tailieunhanh - Báo cáo y học: "Bcl-xL affects the development of functional CD4 Tregs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Bcl-xL affects the development of functional CD4 Tregs. | Sharabi and Mozes Arthritis Research Therapy 2010 12 405 http content 12 4 405 LETTER Bcl-xL affects the development of functional CD4 Tregs Amir Sharabi 1 2 and Edna Mozes1 See related research by Haque etal. http content 12 2 R66 We read with great interest the article by Haque and colleagues 1 in a recent issue of Arthritis Research Therapy. They hypothesized that co-transduction of CD4 T cells with both forkhead box P3 transcription factor FoxP3 and Bcl-xL will generate highly reactive regulatory T cells Tregs that can be used to prevent autoimmune disease. The authors showed that the accumulation persistence and efficient function of Tregs were attributable to the expression of Bcl-xL in CD4 Tregs. Indications for a potential role of Bcl-xL in the development of functional Tregs were first described by our group and the results of studies supporting this notion were published in numerous journals for example 2-5 . Because this information was not mentioned in the article by Haque and colleagues 1 and because the results presented in their article confirm our previous studies 2-5 we think that it is important scientifically and ethically to acknowledge these data. Our group has been studying systemic lupus erythematosus SLE and developed a tolerogenic peptide namely hCDR1 shown to ameliorate manifestations of the disease through several mechanisms of action including the induction of CD4 Tregs 2 . We showed that Bcl-xL was upregulated in CD4 Tregs of SLE-affected NZBxNZW F1 mice following treatment with the tolerogenic peptide 3 . Bcl-xL played a suppressive role in the tolerized mice as it inhibited the activation of T and B cells and mediated the downregulating effects of hCDR1 on the production of the pathogenic cytokines interferon-gamma and interleukin-10 and the upregu-lating effects on the immunosuppressive cytokine transforming growth factor-beta TGF-P . Furthermore CD4 Tregs of the tolerized mice elicited .