tailieunhanh - Báo cáo y học: "TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways. | Perros et al. Respiratory Research 2011 12 125 http content 12 1 125 RESPIRATORY RESEARCH REVIEW Open Access TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways Frederic Perros1 2 Bart N Lambrecht1 and Hamida Hammad1 Abstract Inflammation of the airways which is often associated with life-threatening infection by Gram-negative bacteria or presence of endotoxin in the bioaerosol is still a major cause of severe airway diseases. Moreover inhaled endotoxin may play an important role in the development and progression of airway inflammation in asthma. Pathologic changes induced by endotoxin inhalation include bronchospasm airflow obstruction recruitment of inflammatory cells injury of the alveolar epithelium and disruption of pulmonary capillary integrity leading to protein rich fluid leak in the alveolar space. Mammalian Toll-like receptors TLRs are important signalling receptors in innate host defense. Among these receptors TLR4 plays a critical role in the response to endotoxin. Lungs are a complex compartmentalized organ with separate barriers namely the alveolar-capillary barrier the microvascular endothelium and the alveolar epithelium. An emerging theme in the field of lung immunology is that structural cells SCs of the airways such as epithelial cells ECs endothelial cells fibroblasts and other stromal cells produce activating cytokines that determine the quantity and quality of the lung immune response. This review focuses on the role of TLR4 in the innate and adaptive immune functions of the pulmonary SCs. Keywords Airway diseases dendritic cells epithelial cell pulmonary stromal cells TLR4 TLRs and TLR4 signalling at a glance Cytokines that stimulate the innate immune response are not constitutively expressed but must be called into play by specific signals that alert the host to invading microorganisms. Mammalian Toll-like receptors TLRs are similar in structure and function to the .