tailieunhanh - Báo cáo y học: " Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study. | Nikpour et al. Arthritis Research Therapy 2010 12 R125 http content 12 3 R125 RESEARCH ARTICLE Open Access Varfe bility over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus a longitudinal cohort study Mandana Nikpour 1 2 Dafna D Gladman1 Dominique Ibanez1 Paula J Harvey3 and Murray B Urowitz 1 Abstract Introduction Total cholesterol TC and blood pressure BP are likely to take a dynamic course over time in patients with systemic lupus erythematosus SLE . This would have important implications in terms of using single-point-intime measurements of these variables to assess coronary artery disease CAD risk. The objective of this study was to describe and quantify variability over time of TC and BP among patients with SLE and to determine their correlates. Methods Patients in the Toronto lupus cohort who had two or more serial measurements of TC and systolic and diastolic BP SBP and DBP were included in the analysis. Variability over time was described in terms of the proportion of patients whose TC and BP profile fluctuated between normal and elevated TC mmol L SBP 140 mm Hg or DBP 90 mm Hg and also in terms of within- and between-patient variance quantified by using analysis of variance modeling. Generalized estimating equations GEEs were used to determine independent correlates of each of TC SBP and DBP treated as continuous outcome variables. Results In total 1 260 patients comprising 26 267 measurements of each of TC SBP and DBP were included. Mean SD number of measurements per patient was 20. Mean SD time interval between measurements was months. Mean SD time interval from the start to the end of the study was years. Over time of patients varied between having normal and elevated cholesterol levels whereas the status of of patients varied between normotensive and hypertensive. By using analysis of variance ANOVA the within-patient percentage of total variance for each .

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