tailieunhanh - Báo cáo y học: "Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. | Kawase et al. Respiratory Research 2011 12 97 http content 12 1 97 RESPIRATORY RESEARCH RESEARCH Open Access Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease 1 1 1 1 1 2 Shigeo Kawase Noboru Hattori Nobuhisa Ishikawa Yasushi Horimasu Kazunori Fujitaka Osamu Furonaka I s f p. I I r l- - 3 c I z l I I rr r Po 4 I_I I V I I I_I m s I I4 5 I s I r Pi I s m nv AI ìhìh V s m s 6 I l I I I 1 1 IV r Pk r 1 Takeshi Isobe Seigo Miyoshi Hironobu Hamada Takashi Yamane Akihito Yokoyama and Nobuoki Kohno Abstract Background A high incidence of interstitial lung disease ILD has been reported in patients with advanced nonsmall cell lung cancer NSCLC treated with epidermal growth factor receptor-tyrosine kinase inhibitors EGFR-TKIs particularly in Japanese populations. A previous report from our laboratory demonstrated that KL-6 was a useful serum biomarker to assess the severity of drug-induced pneumonitis. Based on these observations this study was conducted to evaluate the risk factors of EGFR-TKIs induced ILD and the usefulness of monitoring serum KL-6 levels in patients who developed EGFR-TKIs induced ILD in a large multi-institutional setting. Methods We retrospectively reviewed clinical records and radiographies of 341 patients with advanced NSCLCs who were treated with EGFR-TKIs and analyzed risk factors for the development of EGFR-TKIs induced ILD. Changes of circulating levels of KL-6 were also evaluated in the patients who developed EGFR-TKIs induced ILD. Results Among the 341 patients included in this study 20 developed EGFR-TKIs induced ILD and 9 died from ILD. Univariate analyses revealed that only preexisting pulmonary fibrosis was a significant risk factor for the development of EGFR-TKIs induced ILD p . Absolute levels of circulating KL-6 at neither baseline nor the onset of ILD could discriminate between life-threatening and non-life threatening .