tailieunhanh - Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. | Respiratory Research BioMed Central Open Access Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma Yutong Zhao 1 Jiankun Tong1 Donghong He1 Srikanth Pendyala1 Berdyshev Evgeny1 Jerold Chun2 Anne I Sperling1 and Viswanathan Natarajan1 Address Department of Medicine The University of Chicago Chicago Illinois USA and - Department of Molecular Biology The Scripps Research Institute La Jolla California USA Email Yutong Zhao - yzhao@ Jiankun Tong - jtong@ Donghong He - dhe@ Srikanth Pendyala-spendyala@ Berdyshev Evgeny - eberdysh@ Jerold Chun - jchun@ Anne I Sperling - asperlin@ Viswanathan Natarajan - vnataraj@ Corresponding author Published 20 November 2009 Received 28 May 2009 Accepted 20 November 2009 Respiratory Research 2009 10 114 doi 1465-9921-10-114 r This article is available from http content 10 1 114 2009 Zhao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lysophosphatidic acid LPA plays a critical role in airway inflammation through G protein-coupled LPA receptors LPA1-3 . We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation. Methods Wild type LPA1 heterozygous knockout mice LPA1 - and LPA2 heterozygous knockout mice LPA2 - were sensitized with inactivated Schistosoma mansoni eggs and local antigenic challenge with Schistosoma mansoni soluble egg Ag SEA in the