tailieunhanh - Báo cáo y học: " Impaired immune responses in the lungs of aged mice following influenza infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Impaired immune responses in the lungs of aged mice following influenza infection. | Respiratory Research BioMed Central Research Impaired immune responses in the lungs of aged mice following influenza infection Franklin RToapanta 1 2 4 and Ted M Ross 1 2 3 Address 1Center for Vaccine Research University of Pittsburgh Pittsburgh PA USA 2Center for Modeling Pulmonary Immunity University of Pittsburgh Pittsburgh PA USA 3Department of Microbiology and Molecular Genetics University of Pittsburgh Pittsburgh PA USA and 4Current address Center for Vaccine Development 685 West Baltimore Street Health Sciences Facility Bldg 1 HSF-1 University of Maryland School of Medicine Baltimore Maryland 21201 USA Email Franklin RToapanta - frt2@ Ted M Ross - tmr15@ Corresponding authors Open Access Published 18 November 2009 Received 19 April 2009 Respiratory Research 2009 10 112 doi 1465-9921-10-112 Accepted 18 November 2009 This article is available from http content 10 1 1 12 2009 Toapanta and Ross licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Each year influenza virus infection causes severe morbidity and mortality particularly in the most susceptible groups including children the elderly 65 years-old and people with chronic respiratory diseases. Among the several factors that contribute to the increased susceptibility in elderly populations are the higher prevalence of chronic diseases . diabetes and the senescence of the immune system. Methods In this study aged and adult mice were infected with sublethal doses of influenza virus A Puerto Rico 8 1934 . Differences in weight loss morbidity virus titer and the kinetics of lung infiltration with cells of the innate .