tailieunhanh - Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. | Respiratory Research BioMed Central Open Access Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease Thomas Hoehn 1 Brigitte Stiller2 Allan RMcPhaden3 and Roger M Wadsworth4 Address 1Neonatology and Pediatric Intensive Care Medicine Department of General Pediatrics Heinrich-Heine-University Duesseldorf Germany 2Department of Congenital Heart Disease University Hospital Freiburg and Department of Pediatric Cardiology Deutsches Herzzentrum Berlin Germany 3Department of Pathology Glasgow Royal Infirmary Glasgow UK and 4Department of Physiology and Pharmacology University of Strathclyde Glasgow UK Email Thomas Hoehn - Brigitte Stiller - Allan R McPhaden - armp2k@ Roger M Wadsworth - Corresponding author Published 13 November 2009 Received 21 July 2009 Respiratory Research 2009 10 110 doi 1465-9921-10-110 Accepted 13 November 2009 This article is available from http content 10 1 1 10 2009 Hoehn et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rationale Nitric oxide is an important regulator of vascular tone in the pulmonary circulation. Surgical correction of congenital heart disease limits pulmonary hypertension to a brief period. Objectives The study has measured expression of endothelial eNOS inducible iNOS and neuronal nitric oxide synthase nNOS in the lungs from biopsies of infants with pulmonary hypertension secondary to cardiac abnormalities n 26 compared to a control group who did not have pulmonary or cardiac disease n 8 . Methods eNOS iNOS and nNOS were identified by immunohistochemistry and quantified in .