tailieunhanh - Báo cáo y học: " Increased levels of (class switched) memory B cells in peripheral blood of current smokers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Increased levels of (class switched) memory B cells in peripheral blood of current smokers. | Respiratory Research BioMed Central Research Increased levels of class switched memory B cells in peripheral blood of current smokers Corry-Anke Brandsma 1 2 Machteld N Hylkema2 Marie Geerlings1 2 Wouter H van Geffen1 Dirkje S Postma1 Wim Timens2 and Huib AM Kerstjens1 Address Department of Pulmonary Diseases University Medical Center Groningen University of Groningen . Box 9700 RB Groningen The Netherlands and 2Department of Pathology University Medical Center Groningen University of Groningen . Box 9700 RB Groningen The Netherlands Email Corry-Anke Brandsma - Machteld N Hylkema - Marie Geerlings - Wouter H van Geffen - Dirkje S Postma - Wim Timens - Huib AM Kerstjens - Corresponding author Open Access Published 12 November 2009 Received 13 May 2009 Respiratory Research 2009 10 108 doi l465-992l-l0-l08 Accepted 12 November 2009 This article is available from http content l0 l 108 2009 Brandsma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ There is increasing evidence that a specific immune response contributes to the pathogenesis of COPD. B-cell follicles are present in lung tissue and increased anti-elastin titers have been found in plasma of COPD patients. Additionally regulatory T cells Tregs have been implicated in its pathogenesis as they control immunological reactions. We hypothesize that the specific immune response in COPD is smoke induced either by a direct effect of smoking or as a .

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