tailieunhanh - Báo cáo y học: " Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia. | Respiratory Research BioMed Central Research Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia Audra A Winder1 Christine Wohlford-Lenane1 Todd E Scheetz2 5 Brie N Nardy3 Lori J Manzel3 Dwight C Look3 and Paul B McCray Jr 1 3 4 Open Access Address Department of Pediatrics Carver College of Medicine University of Iowa Iowa City IA USA 2Department of Opthalmology Carver College of Medicine University of Iowa Iowa City IA USA 3Department of Internal Medicine Carver College of Medicine University of Iowa Iowa City IA USA 4Department of Microbiology Carver College of Medicine University of Iowa Iowa City IA USA and 5College of Engineering University of Iowa Iowa City IA USA Email Christine Wohlford-Lenane - c-wohlford-lenane@ Todd E Scheetz - todd-scheetz@ Brie N Nardy - brie-nardy@ Lori J Manzel - lori-manzel@ Dwight C Look - dwight-look@ Paul B McCray - paul-mccray@ Corresponding author Published 16 October 2009 Received 10 February 2009 Respiratory Research 2009 10 96 doi 1465-9921-10-96 Accepted 16 October 2009 This article is available from http content 10 1 96 2009 Winder et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The recognition of microbial molecular patterns via Toll-like receptors TLRs is critical for mucosal defenses. Methods Using well-differentiated primary cultures of human airway epithelia we investigated the effects of exposure of the cells to cytokines TNF-a and IFN-y and dexamethasone dex on responsiveness to the TLR2 TLR1 ligand Pam3CSK4. Production of IL-8 CCL20 and .