tailieunhanh - Báo cáo y học: " Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. | Respiratory Research BioMed Central Research Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model Guan-Hong Shang 1 Dian-Jie Lin2 Wei Xiao1 Chong-Qi Jia3 Yu Li1 Ai- Hua Wang1 and Liang Dong1 Address Department of Respiratory Medicine Qilu Hospital School of Medicine Shandong University Jinan 250012 PR China 2Department of Respiratory Medicine Shandong Province Hospital School of medicine Shandong University Jinan 250012 PR China and 3Department of Epidemiology and Health Statistics Shandong University Jinan 250012 PR China Email Guan-Hong Shang - shangguanhong0516@ Dian-Jie Lin-ldjslyy01@ WeiXiao-xwqlyyhx@ Chong-Qi Jia - chongqijia@ Yu Li - qlliyu@ Ai-Hua Wang - wahqlyyy@ Liang Dong - dlqlyyu@ Corresponding author Open Access Published 2 October 2009 Received I April 2009 Respiratory Research 2009 10 91 doi 1465-9921-10-91 Accepted 2 October 2009 This article is available from http content 10 1 91 2009 Shang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Ethyl pyruvate EP was recently identified as an experimental therapeutic agent in a wide variety of model systems for inflammation-mediated tissue and cellular injury. Objective To evaluate the effect of ethyl EP on improving the survival in mice with LPS-induced acute lung injury ALI . Methods ALI was induced by administering lipopolysaccharide LPS intratracheally. The mice were treated intraperitoneally . with 1 00 50 and 10 mg kg EP immediately before intratracheal instillation of LPS and 1 00 mg kg EP was administered 0 1 2 24