tailieunhanh - Báo cáo y học: " Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response. | Respiratory Research BioMed Central Open Access Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response Sadatomo Tasaka 1 Hirofumi Kamata1 Keisuke Miyamoto1 Yasushi Nakano1 Hiromi Shinoda1 Yoshifumi Kimizuka1 Hiroshi Fujiwara1 Naoki Hasegawa1 Seitaro Fujishima2 Taku Miyasho3 and Akitoshi Ishizaka1 Address division of Pulmonary Medicine Keio University School of Medicine Tokyo Japan - Department of Emergency and Critical Care Medicine Keio University School of Medicine Tokyo Japan and laboratory of Veterinary Biochemistry Rakuno Gakuen University Ebetsu Japan Email Sadatomo Tasaka - tasaka@ Hirofumi Kamata - oklahoma-westcoast@ Keisuke Miyamoto - beachbreak@ Yasushi Nakano - keio_yas@ Hiromi Shinoda - hiromiseki0513@ Yoshifumi Kimizuka - kimi@ Hiroshi Fujiwara - lecafe1979@ Naoki Hasegawa - hasegawn@ Seitaro Fujishima - fujishim@ Taku Miyasho - taku-m@ Akitoshi Ishizaka - ishizaka@ Corresponding author Published 23 September 2009 Received 6 July 2009 Respiratory Research 2009 10 84 doi 1465-9921-10-84 Accepted 23 September 2009 This article is available from http content 10 1 84 2009 Tasaka et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Bacterial genome is characterized by frequent unmethylated cytosine-phosphate-guanine CpG motifs. Deleterious effects can occur when synthetic oligodeoxynucleotides ODN with unmethylated CpG dinucleotides CpG-ODN are administered in a systemic fashion. We aimed to evaluate the effect of intratracheal CpG-ODN on lung inflammation .