tailieunhanh - Báo cáo y học: " Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD. | Al-shair et al. Respiratory Research 2011 12 3 http content 12 1 3 RESPIRATORY RESEARCH RESEARCH Open Access Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD 1 1 1 2 1 Khaled Al-shair Umme Kolsum Rachel Dockry Julie Morris Dave Singh Jorgen Vestbo Abstract Introduction COPD is an inflammatory disease with major co-morbidities. It has recently been suggested that depression may be the result of systemic inflammation. We aimed to explore the association between systemic inflammation and symptoms of depression and fatigue in patients with mainly moderate and clinically stable COPD using a range of inflammatory biomarkers 2 depression and 2 fatigue scales. Method We assessed 120 patients with moderate COPD FEV1 52 men 62 age 66 . Depression was assessed using the BASDEC and CES-D scales. Fatigue was assessed using the Manchester COPD-fatigue scale MCFS and the Borg scale before and after 6MWT. We measured systemic TNF-a CRP TNF-a-R1 TNF-a-R2 and IL-6. Results A multivariate linear model of all biomarkers showed that TNF-a only had a positive correlation with BASDEC depression score p . TNF-a remained positively correlated with depression p after further adjusting for TNF-a-R1 TNF-a-R2 6MWD FEV1 and pack-years. Even after adding the MCFS score body mass and body composition to the model TNF-a was still associated with the BASDEC score p . Furthermore patients with higher TNF-a level 3 pg ml n 7 had higher mean CES-D depression score than the rest of the sample p . Borg fatigue score at baseline were weakly correlated with TNF-a and CRP and with TNF-a only after 6MWT. Patients with higher TNF-a had more fatigue after 6MWD p . Conclusion This study indicates a possible association between TNF-a and two frequent and major co-morbidities in COPD . depression and fatigue. Introduction COPD is a chronic inflammatory disease with systemic manifestations such as muscle