tailieunhanh - Báo cáo y học: " Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study. | Lee et al. Respiratory Research 2011 12 1 http content 12 1 1 RESPIRATORY RESEARCH RESEARCH Open Access Smoking longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma findings from the COREA study 11 112 3 1 Taehoon Lee Yoon Su Lee Yun-Jeong Bae Tae-Bum Kim Seon Ok Kim Sang-Heon Cho Hee-Bom Moon cohort for Reality and Evolution of adult Asthma in Korea study group COREA study group 1 You Sook Cho1 Abstract Background The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma. Methods Severe asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction FAO forced expiratory volume in 1 second FEV1 forced vital capacity FVC ratio n 119 and the other had reversible airway obstruction RAO FEV1 FVC ratio n 116 . Clinical and demographic parameters were compared between the two groups. Results Multivariate analysis showed that longer duration of disease greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters including atopic status pattern of airway inflammatory cells in induced sputum and frequency of asthma exacerbations did not differ between the FAO and RAO groups. Conclusion Severe asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease .