tailieunhanh - Báo cáo y học: " Cyclic hydrostatic pressure and cotton particles stimulate synthesis by human lung macrophages of cytokines in vitro"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Cyclic hydrostatic pressure and cotton particles stimulate synthesis by human lung macrophages of cytokines in vitro. | Respiratory Research BioMed Central Research Cyclic hydrostatic pressure and cotton particles stimulate synthesis by human lung macrophages of cytokines in vitro Sarah Lewis1 Dave Singh2 and Carol E Evans 1 Open Access Address Tissue Injury and Repair Group School of Clinical and Laboratory Sciences Faculty of Medical and Human Sciences University of Manchester Stopford Building Oxford Road Manchester M13 9PT UK and 2NIHR Translational Research Facility University Of Manchester University Hospital Of South Manchester Foundation Trust UK Email Sarah Lewis - Dave Singh - dsingh@ Carol E Evans - Corresponding author Published 2 June 2009 Received 8 August 2007 Respiratory Research 2009 10 44 doi 1465-9921-10-44 Accepted 2 June 2009 This article is available from http content 10 1 44 2009 Lewis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inhalation of particulates is a leading cause of the development of lung diseases and current understanding of the complex relationship between lung metabolism and airborne particulates is incomplete. It is well established that mechanical load is important in the development of the lung and in lung cell differentiation. The interaction between particle exposure and physical forces on alveolar macrophages is a physiologically relevant issue but as yet understudied. This study examines the effect of cyclic hydrostatic pressure and cotton particles on synthesis of cytokines by human alveolar macrophages. Methods Alveolar macrophages were obtained from patients with lung disease either from lavage samples or from lung tissue resection. The commonly used cell line THP-1 .

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