tailieunhanh - Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis. | Respiratory Research BioMed Central Research Altered expression of T cell Immunoglobulin-Mucin TIM molecules in bronchoalveolar lavage CD4 T cells in sarcoidosis Farah Idali 1 2 Jan Wahlstrom1 Benita Dahlberg1 Mohsen Khademi3 Tomas Olsson3 Anders Eklund1 and Johan Grunewald1 Open Access Address Department of Medicine Unit of Respiratory Medicine Karolinska Institutet Stockholm Sweden 2Monoclonal Antibody Research Center Avicenna Research Institute ACECR Tehran Iran and 3Department of Clinical Neuroscience Unit of Neuroimmunology Karolinska Institutet Stockholm Sweden Email Farah Idali - Jan Wahlstrom - Benita Dahlberg - Mohsen Khademi - Tomas Olsson - Anders Eklund - Johan Grunewald - Corresponding author Published 29 May 2009 Received 17 September 2008 Respiratory Research 2009 10 42 doi 1465-9921-10-42 Accepted 29 May 2009 This article is available from http content 10 1 42 2009 Idali et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Activated T helper Th -1 pulmonary CD4 cells and their mediators are essential for the inflammation and granulomatous process in sarcoidosis. Recently T-cell immunoglobulin and mucin domain TIM molecules were suggested to be important regulators of immune function. In this study we wanted to investigate whether TIM molecules could play a role in sarcoidosis. Methods We used real-time polymerase chain reaction to investigate the differential gene expression of TIM-1 and TIM-3 as well as a few Th1 and Th2 .

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