tailieunhanh - Báo cáo y học: "A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. | Respiratory Research BioMed Central Research A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice Marylène Fortin11 Hélène D Anjou11 Marie-Ève Higgins1 Jasmine Gougeon1 Paméla Aubé1 Kamel Moktefi1 Sonia Mouissi1 Serge Séguin1 Rosanne Séguin1 Paolo M Renzi1 2 Luc Paquet3 and Nicolay Ferrari 1 Open Access Address Topigen Pharmaceuticals Inc 2901 Rachel Street East Room 13 Montreal Quebec H1W 4A4 Canada 2CHUM Research Center Notre-Dame Hospital 2065 Alexandre de Sève Room Z-8905 Montreal Quebec H2L 2W5 Canada and 3Institut de Pharmacologie Université de Sherbrooke 3001 12e Avenue Nord Sherbrooke Quebec J1H 5N4 Canada Email Marylène Fortin - Hélène D Anjou - Marie-Ève Higgins - Jasmine Gougeon - jasg29@ Paméla Aubé - pam_aube@ Kamel Moktefi - Sonia Mouissi - Serge Séguin - Rosanne Séguin - Paolo M Renzi - Luc Paquet - Nicolay Ferrari - Corresponding author fEqual contributors Published 20 May 2009 Received 13 February 2009 Respiratory Research 2009 10 39 doi l465-992l-l0-39 Accepted 20 May 2009 This article is available from http content l0 l 39 2009 Fortin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent development in the field of COPD has focused on strategies aimed at reducing the underlying inflammation through selective inhibition of the phosphodiesterase type IV PDE4 isoform. Although the anti-inflammatory and .