tailieunhanh - Báo cáo y học: " Fibrocytes and the tissue niche in lung repair"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Fibrocytes and the tissue niche in lung repair. | Andersson-Sjoland et al. Respiratory Research 2011 12 76 http content 12 1 76 RESPIRATORY RESEARCH REVIEW Open Access Fibrocytes and the tissue niche in lung repair Annika Andersson-Sjoland 1 Kristian Nihlberg1 Leif Eriksson2 Leif Bjermer2 and Gunilla Westergren-Thorsson1 2 Abstract Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However plasticity of a niche may be co-opted in chronic airway diseases such as asthma idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases. Introduction Tissue repair and remodelling are ongoing processes in all types of wound healing. In healthy subjects the primary role of the extracellular matrix ECM is to provide tissues with specific mechanical properties and to serve as a structural framework for cell attachment and migration. An ongoing tissue repair can result in fibrosis which is regarded as an abnormal wound-healing process. Both resident tissue cells and recruited cells play significant roles in the pathological tissue repair. Mesenchymal stem cells and progenitor cells have recently emerged as being important for maintaining tissue homeostasis. The dynamic relationship between the stem cells and the niche is very evident during tissue repair after an injury. Constitutive activation of repair programs including accompanying inflammatory responses leads to permanent changes in the niche that can lead to dysregulation of

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