tailieunhanh - Báo cáo y học: " Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. | Respiratory Research BioMed Central Research Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats Hsao-Hsun Hsu1 2 Wen-Je Ko1 3 Jo-Yu Hsu1 Jin-Shing Chen1 Yung- Chie Lee1 I-Rue Lai1 and Chau-Fong Chen 2 Address Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan ROC 2Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan ROC and 3Department of Traumatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan ROC Email Hsao-Hsun Hsu - ntuhfred@ Wen-Je Ko - kowj@ Jo-Yu Hsu - rorofi@ Jin- Shing Chen - chenjs@ Yung-Chie Lee - yclee@ I-Rue Lai - irulai@ Chau-Fong Chen - chfochen@ Corresponding author Open Access Published 2 May 2009 Received 21 January 2009 Respiratory Research 2009 10 32 doi l465-992l-l0-32 Accepted 2 May 2009 This article is available from http content l0 l 32 2009 Hsu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Simvastatin has been shown to ameliorate pulmonary hypertension by several mechanisms in experimental animal models. In this study we hypothesized that the major benefits of simvastatin in pulmonary hypertension occur via the heme oxygenase-l pathway. Methods Simvastatin 10 mg kgw day was tested in two rat models of pulmonary hypertension PH monocrotaline administration and chronic hypoxia. The hemodynamic changes right heart hypertrophy HO-l protein expression and heme oxygenase HO