tailieunhanh - Báo cáo y học: "Ascorbic acid pre-treated quartz stimulates TNF-α release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Ascorbic acid pre-treated quartz stimulates TNF-α release in RAW murine macrophages through ROS production and membrane lipid peroxidation. | Respiratory Research BioMed Central Open Access Ascorbic acid pre-treated quartz stimulates TNF-a release in RAW murine macrophages through ROS production and membrane lipid peroxidation Sonia Scarfl 1 2 Mirko Magnone1 Chiara Ferraris2 Marina Pozzolini2 Federica Benvenuto3 Umberto Benatti1 and Marco Giovine4 Address Department of Experimental Medicine Section of Biochemistry University of Genova 16132 Genova Italy 2Advanced Biotechnology Center 16132 Genova Italy 3Neuroimmunology Unit Department of Neurosciences Ophthalmology and Genetics and Center of Excellence for Biomedical Research University of Genova 16132 Genova Italy and 4Department of Biology University of Genova 16132 Genova Italy Email Sonia Scarfl - soniascarfi@ Mirko Magnone - Chiara Ferraris - Marina Pozzolini - Federica Benvenuto - febenvenuto@ Umberto Benatti - benatti@ Marco Giovine - mgiovine@ Corresponding author Published 19 March 2009 Received I August 2008 Respiratory Research 2009 10 25 doi 1465-9921-10-25 Accepted 19 March 2009 This article is available from http content I0 I 25 2009 Scarfì et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inhalation of crystalline silica induces a pulmonary fibrotic degeneration called silicosis caused by the inability of alveolar macrophages to dissolve the crystalline structure of phagocytosed quartz particles. Ascorbic acid is capable of partially dissolving quartz crystals leading to an increase of soluble silica concentration and to the generation of new radical sites on the quartz surface. The reaction is specific for the crystalline forms of