tailieunhanh - Báo cáo y học: "Dysregulated apoptosis and NFκB expression in COPD subjects"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Dysregulated apoptosis and NFκB expression in COPD subjects. | Respiratory Research BioMed Central Research Dysregulated apoptosis and NFkB expression in COPD subjects Vanessa Brown 1 J Stuart Elborn1 Judy Bradley2 and Madeleine Ennis1 Open Access Address Respiratory Research Group Centre for Infection and Immunity School of Medicine Dentistry and Biomedical Sciences Queen s University Belfast Belfast UK and institute of Rehabilitation Studies University of Ulster Coleraine UK Email Vanessa Brown - J Stuart Elborn - Judy Bradley - Madeleine Ennis - Corresponding author Published 18 March 2009 Received 23 October 2008 Respiratory Research 2009 10 24 doi l465-992l-l0-24 Accepted 18 March 2009 This article is available from http content l0 l 24 2009 Brown et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The abnormal regulation of neutrophil apoptosis may contribute to the ineffective resolution of inflammation in chronic lung diseases. Multiple signalling pathways are implicated in regulating granulocyte apoptosis in particular NFkB nuclear factor-kappa B signalling which delays constitutive neutrophil apoptosis. Although some studies have suggested a dysregulation in the apoptosis of airway cells in chronic obstructive pulmonary disease COPD no studies to date have directly investigated if NFkB is associated with apoptosis of airway neutrophils from COPD patients. The objectives of this study were to examine spontaneous neutrophil apoptosis in stable COPD subjects n 13 healthy smoking controls n 9 and non-smoking controls n 9 and to investigate whether the neutrophil apoptotic process in inflammatory conditions is associated with NFkB

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