tailieunhanh - Báo cáo y học: " Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps. | Respiratory Research BioMed Central Research Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps Geng Xu1 Jiahong Xia2 Xiaoyang Hua2 Han Zhou3 Chuanzhao Yu3 Zheng Liu2 Kemin Cai3 Jianbo Shi1 and Huabin Li 1 3 Open Access Address 1Allergy and Cancer Center Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University and Otorhinolaryngology Institute of Sun Yat-sen University Guangzhou PR China 2Department of Surgery Tongji Medical College Huazhong University of Science and Technology Wuhan PR China and 3Department of Otolaryngology the First Affiliated Hospital of Nanjing Medical University Nanjing PR China Email Geng Xu - entxgfess@ Jiahong Xia - xiajiahong@ Xiaoyang Hua - tigerhuatj@ Han Zhou - zhouhan79@ Chuanzhao Yu - yunchunzhao@ Zheng Liu - zhengliuent@ Kemin Cai - caikemin@ Jianbo Shi - tsjbent@ Huabin Li - allergyli@ Corresponding author Published 27 February 2009 Received 28 July 2008 Respiratory Research 2009 10 13 doi 1465-9921-10-13 Accepted 27 February 2009 This article is available from http content 10 1 13 2009 Xu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Decreased infiltration of Foxp3 T regulatory cell Treg is considered to be critical for the Th1 Th2 dysregulation of nasal polyps while the cellular mechanism underlying Foxp3 Treg insufficiency is currently not well defined. Methods We attempted to investigate the tissue expression of phosphorylated mammalian target of rapamycin pmTOR and infiltration of Foxp3 Tregs in 28 nasal polyps and 16 controls by histological staining. We also .