tailieunhanh - Báo cáo y học: "Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model. | Respiratory Research BioMed Central Open Access Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model Lars Luthje 1 Tobias Raupach1 Hellmuth Michels1 Bernhard Unsold1 Gerd Hasenfuss1 Harald Kogler1 and Stefan Andreas2 Address 1Kardiologie und Pneumologie Georg-August-Universitat Gottingen Germany and 2Lungenfachklinik Immenhausen Kassel Germany Email Lars Luthje - larsluethje@ Tobias Raupach - raupach@ Hellmuth Michels - hmichels@ Bernhard Unsold - unsold@ Gerd Hasenfuss - ghasenfu@ Harald Kogler - Stefan Andreas - sandreas@ Corresponding author Published 28 January 2009 Received 23 September 2008 Respiratory Research 2009 10 7 doi 1465-9921-10-7 Accepted 28 January 2009 This article is available from http content 10 1 7 2009 Luthje et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Systemic effects of chronic obstructive pulmonary disease COPD significantly contribute to severity and mortality of the disease. We aimed to develop a COPD emphysema model exhibiting systemic manifestations of the disease. Methods Female NMRI mice were treated 5 times intratracheally with porcine pancreatic elastase emphysema or phosphate-buffered saline control . Emphysema severity was quantified histologically by mean linear intercept exercise tolerance by treadmill running distance diaphragm dysfunction using isolated muscle strips pulmonary hypertension by measuring right ventricular pressure and neurohumoral activation by determining urinary norepinephrine concentration. Results Mean linear intercept was higher in .

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