tailieunhanh - Báo cáo y học: " Relationship between FEV1 change and patientreported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Relationship between FEV1 change and patientreported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. | Westwood et al. Respiratory Research 2011 12 40 http content 12 1 40 RESPIRATORY RESEARCH REVIEW Open Access Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD a systematic review Marie Westwood 1 Jean Bourbeau2 Paul W Jones3 Annamaria Cerulli4 Gorana Capkun-Niggli4 and Gill Worthy1 Abstract Background Interactions between spirometry and patient-reported outcomes in COPD are not well understood. This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with bronchodilator therapy. Methods Six databases to October 2009 were searched to identify studies with long-acting bronchodilator therapy reporting FEV1 and health status dyspnoea or exacerbations. Mean and standard deviations of treatment effects were extracted for each arm of each study. Relationships between changes in trough FEV1 and outcomes were assessed using correlations and random-effects regression modelling. The primary outcome was St George s Respiratory Questionnaire SGRQ total score. Results Thirty-six studies 3 months were included. Twenty-two studies 23 654 patients with 49 treatment arms each contributing one data point provided SGRQ data. Change in trough FEV1 and change in SGRQ total score were negatively correlated r p greater increases in FEV1 were associated with greater reductions improvements in SGRQ. The correlation strengthened with increasing study duration from 3 to 12 months. Regression modelling indicated that 100 mL increase in FEV1 change at which patients are more likely to report improvement was associated with a statistically significant reduction in SGRQ of 95 CI while a clinically relevant SGRQ change was associated with 95 CI mL increase in FEV1. The association between change in FEV1 and other patient-reported outcomes was generally weak. Conclusions Our .

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